DescriptionDetails of Research Project:
Site-specific intestinal macrophage subtyping in health & inflammatory bowel diseases.
- To decipher site-specific macrophage subtypes in the healthy human intestine. We aim to generate a comprehensive map of macrophage populations, focusing on regional differences between the left and right colon and the ileum. Using a multimodal, high-dimensional approach – including scRNA-seq, flow cytometry, spatial transcriptomics, and multiplexed histology – we will analyze intestinal biopsies to characterize macrophage phenotypes, spatial localization, and transcriptional profiles.
- To decipher IBD-specific macrophage subtypes across inflamed and uninflamed intestinal regions. Building upon the healthy tissue atlas, we will apply the same multimodal, high-dimensional approach – encompassing scRNA-seq, flow cytometry, spatial transcriptomics, and multiplexed histology – to characterize site-specific macrophage populations in patients with Ulcerative colitis and Crohn’s disease.
- To evaluate macrophage profiles as predictive biomarkers of therapeutic response in IBD. We hypothesize that distinct, site-specific macrophage signatures are predictive of response to targeted therapy. To test this, we will establish a longitudinal patient cohort undergoing anti-IL-23 therapy, with intestinal biopsies collected prior to treatment initiation and during therapy.
ResponsibilitiesGoals/Outcomes of the Research Project:
With our multimodal approach, we want to generate a high-resolution atlas of macrophage heterogeneity across distinct intestinal regions, establishing a critical baseline for comparison in disease states.
By applying our analyses to patients with inflammatory bowel disease (IBD) will uncover alterations in the macrophage compartment across different intestinal sites during active and quiescent inflammation, providing critical insights into the role of macrophages in the pathogenesis of IBD.
In a group of patients with Crohn’s disease undergoing anti-IL-23 therapy we will characterize the macrophage compartment over time. Integration of these data with clinical and endoscopic outcomes through advanced bioinformatic analyses will assess the potential of macrophage profiles as predictive biomarkers of therapeutic response in IBD.
QualificationsTechnical Duties: (include any protocols)
scRNA-seq, flow cytometry, spatial transcriptomics, and multiplexed histology performed on patient samples (intestinal biopsies).
Educational and other Requirements for the position: doctoral degree (MD), research experience, communication skills
Experience Required: research experience including scientific publications
Employer DescriptionStrength through Unity and Inclusion
The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.
About the Mount Sinai Health System:
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
Equal Opportunity Employer
The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
