DescriptionTitle: Postdoctoral fellow
Salary: Union-agreed
Department: Neuroscience
Physical work location: (must be proper street address): 3 E 101st St, New York 10029
Name PI or Supervisor: (include phone and email): Jack Humphrey, 646 244 6882, jack.humphrey@mssm.edu
Web link to Lab: www.humphreylab.org
Web link to Department: https://icahn.mssm.edu/about/departments-offices/neuroscience
Administrative Contact: (phone and email): Gloria Yuan, gloria.yuan@mssm.edu (212) 659-5914
ResponsibilitiesDetails of Research Project:
The postdoctoral fellow will lead projects funded by the BrightFocus Foundation and My Name’5 Doddie to explore the role of TDP-43 in affecting gene expression and RNA splicing in the diseases Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and Alzheimer’s Disease (AD).
The projects will combine analysis of bulk tissue and single-cell transcriptomics with both short-read and long-read RNA-seq to identify rare cellular populations and rare mRNA isoforms in the spinal cord associated with ALS, the frontal cortex in FTD, and the hippocampus in AD, and assess how these cells and isoforms are associated with disease pathology, disease progression, and genetic risk factors.
The candidate will have access to human patient tissues from the Mount Sinai Neuropathology Brain Bank, the Target ALS postmortem tissue collection, and the University College London Queen Square Brain Bank. The candidate will join international consortia with labs across the US and UK, and attend regular monthly virtual meetings to present progress and discuss with the other groups. The candidate will attend yearly in-person meetings to present their results to a wider audience, and meet in person with the other consortium members.
The candidate will join a multidisciplinary research team that includes geneticists, computational biologists, immunologists, pathologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer’s Disease within the Icahn School of Medicine at Mount Sinai. The candidate will be mentored by Dr Jack Humphrey in the Department of Neuroscience.
QualificationsTechnical Duties: (include any protocols)
Single-cell/nucleus RNA-seq analysis
Genetics of both rare and common variation
Long-read RNA-seq
Spatial Transcriptomics
Educational and other Requirements for the position: PhD in Neuroscience and/or computational biology with a focus on TDP-43 in ALS, FTD, or AD.
Experience Required:
Experience with single-cell datasets
Experience with genetics
Experience with RNA splicing analysis
Experience working with TDP-43 datasets
Experience re-analysing public datasets
Goals/Outcomes of the Research Project:
This work could lead to a better understanding of cellular interactions in the nervous system, and how the neuronal response to specific protein pathologies shapes the course of disease. This work could lead to new biomarkers for disease progression and new therapeutic targets.
Compensation Statement
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 867 - Neurosciences - ISM, Icahn School of Medicine
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Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
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Compensation
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
