Exciting Opportunity at MSK: The Romesser Lab is looking for a Postdoctoral Fellow to join our team studying therapy induced senescence and tumor immunology.
Role Overview
Dr. Paul Romesser’s laboratory is recruiting abold and innovativePostdoctoral Fellowtoturn cellular senescence into a weaponized immunologic state against cancer. Rooted in rectal cancer—but engineered to translate across immune‑refractory tumors—our program fusesimmunocompetent mouse models, patient‑derived organoids, single‑cell / spatial multi‑omics, and CRISPR‑based functional genomics. You willdrive NIH‑ and foundation‑funded projectsthat dissect the senescence–immune interface and fast‑track novel combination therapies toward first‑in‑human trials, all within MSK’s collaborative, technology‑rich ecosystem.
Key Requirements:
- PhD or MD/PhDin Cancer Biology, Immunology, Molecular Biology, or a related discipline
- Hands on expertise in at least one of the following:
- Immunocompetent mouse tumor models
- Patient‑derived organoid culture and manipulation
- Flow cytometry or advanced immune-profiling platforms
- Single‑cell or spatial omics
- Computational proficiency—familiarity with R/Python for analysis of bulk, single‑cell, or spatial‑omics data (or a strong willingness to learn).
- Strong publication recordthat highlights independent thinking and problem‑solving.
- Excellent communication skills(written and oral) and a track record of productive collaboration within interdisciplinary teams.
Core Skills:
- Experimental Design & Troubleshooting: Ability to conceptualize, execute, and optimize complex in vivo (mouse) and ex vivo (organoid) studies, including CRISPR perturbations and multiplex assays.
- Single‑Cell & Spatial Multi‑omics: Competence in generating and/or analyzing scRNA‑seq and spatial transcriptomics data; comfortable using pipelines such as Seurat, Scanpy, or equivalent.
- Data Analysis & Visualization: Fluency in R/Python for statistics, data integration, and production‑quality figures that clearly communicate findings to diverse audiences.
- Immunological Assays: Proficiency with flow cytometry, ELISA/LEGENDplex, functional T‑cell or myeloid assays, and lymphoid and myeloid co-culture assays for dissecting tumor–immune interactions.
- Scientific Communication & Leadership: Strong track record of manuscript preparation, conference presentations, and collaborative project management; ability to mentor junior trainees and foster an inclusive lab culture.
Application Instruction:
Submit C.V., letter of interest, and references in your application submission to:
Contact Name: Tiara Williamson
Contact Email: WilliT11@mskcc.org
Pay Range: $72,000 to $113,900
Learn more about working as a Post-Doctoral at MSK: Discover MSK’s world‑class core facilities, multidisciplinary mentorship, and robust career‑development programs at https://www.mskcc.org/postdoctoral. As a fellow, you’ll leverage cutting‑edge technologies—ranging from single‑cell and spatial‑omics platforms to premier animal and organoid cores—while collaborating across oncology, immunology, and computational biology. This uniquely collaborative ecosystem accelerates transformative science into therapies that improve patient outcomes worldwide.
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